| 产品名称 | Anti-ETS1 antibody |
| 产品货号 | BO3058 |
| 交叉反应 | human, mouse, rat |
| 应用范围 | WB, IHC，IF |
| 推荐稀释比 | WB 1:1000-2000, IHC 1:50-300，IF 1:200 |
| 蛋白分子量 | 25/30/40/50/55KDa |
| 抗体来源 | Rabbit |
| 产品类型 | Polyclonal Antibody |
| 性状 | Liquid |
| 储存 | -20℃ |
| 背景资料 | ETS-1 is a proto-oncoprotein that belongs to the E26 Transformation-specific Sequence (ETS) family of transcription factors that share a unique and highly conserved DNA binding domain. ETS-1 plays important roles in vascular development and angiogenesis, and vascular inflammation and remodeling. The target genes of ETS-1 include receptor tyrosine kinases, MMPs, and cell adhesion molecules. In addition, ETS-1 is involved in regulation of energy metabolism in cancer cells. ETS-1 activity is regulated by two different types of phosphorylation sites. While phosphorylation at a cluster of serine residues in the exon VII domain by CaMKII inhibits ETS-1 DNA binding activity, phosphorylation at its Thr38 site by Ras activates ETS-1. |
