| 产品名称 | Anti-Gsk3β antibody |
| 产品货号 | BO1206 |
| 交叉反应 | human, mouse, rat |
| 应用范围 | WB, IHC |
| 推荐稀释比 | WB 1:1000-2000, IHC 1:50-100 |
| 蛋白分子量 | 47kDa |
| 抗体来源 | Rabbit |
| 产品类型 | Polyclonal Antibody |
| 性状 | Liquid |
| 储存 | -20℃ |
| 背景资料 | Glycogen synthase kinase-3 (GSK-3) was initially identified as an enzyme that regulates glycogen synthesis in response to insulin. GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 is a critical downstream element of the PI3K/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3β. In contrast, the phosphorylation of tyrosine 216 of GSK-3β or tyrosine 279 of GSK-3α in the catalytic domain increase this kinase activity to promote cell death under the absence of growth factors. GSK-3 has been implicated in the regulation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus, and mammalian development. GSK-3 has been shown to regulate cyclin D1 proteolysis and subcellular localization. |
