| 产品名称 | Anti-SMAD7 antibody |
| 产品货号 | BO1110 |
| 交叉反应 | human, mouse, rat |
| 应用范围 | WB, IHC |
| 推荐稀释比 | WB 1:500-1000, IHC 1:50-200 |
| 蛋白分子量 | 46kDa |
| 抗体来源 | Rabbit |
| 产品类型 | Polyclonal Antibody |
| 性状 | Liquid |
| 储存 | -20℃ |
| 背景资料 | The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. |
